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Iron Chelation Therapy for Malaria

Identifieur interne : 002612 ( Main/Exploration ); précédent : 002611; suivant : 002613

Iron Chelation Therapy for Malaria

Auteurs : George F. Mabeza [Zimbabwe] ; Mark Loyevsky [États-Unis] ; Victor R. Gordeuk [États-Unis] ; Günter Weiss [Autriche]

Source :

RBID : ISTEX:8E574E592257E2C1BA52C8AD66312053838F77FE

English descriptors

Abstract

Abstract: Malaria is one of the major global health problems, and an urgent need for the development of new antimalarial agents faces the scientific community. A considerable number of iron(III) chelators, designed for purposes other than treating malaria, have antimalarial activity in vitro, apparently through the mechanism of withholding iron from vital metabolic pathways of the intra-erythrocytic parasite. Certain iron(II) chelators also have antimalarial activity, but the mechanism of action appears to be the formation of toxic complexes with iron rather than the withholding of iron. Several of the iron(III)-chelating compounds also have antimalarial activity in animal models of plasmodial infection. Iron chelation therapy with desferrioxamine, the only compound of this nature that is widely available for use in humans, has clinical activity in both uncomplicated and severe malaria in humans.

Url:
DOI: 10.1016/S0163-7258(98)00037-0


Affiliations:


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Le document en format XML

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<term>Aminolevulinate synthase</term>
<term>Animal models</term>
<term>Antimalarial</term>
<term>Antimalarial action</term>
<term>Antimalarial activity</term>
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<term>Antimalarial therapy</term>
<term>Antiparasitic effect</term>
<term>Aotus monkeys</term>
<term>Aromatic chelators</term>
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<term>Beneficial effect</term>
<term>Beneficial effects</term>
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<term>Bind iron</term>
<term>Biochem</term>
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<term>Blood cell</term>
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<term>Cabantchik</term>
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<term>Cerebral</term>
<term>Cerebral malaria</term>
<term>Cerebral malaria patients</term>
<term>Chelation</term>
<term>Chelator</term>
<term>Chelators</term>
<term>Churchill livingstone</term>
<term>Clin</term>
<term>Coma</term>
<term>Confidence interval</term>
<term>Coordination sites</term>
<term>Cytokine</term>
<term>Cytotoxic</term>
<term>Cytotoxicity</term>
<term>Deep coma</term>
<term>Deferiprone</term>
<term>Derivative</term>
<term>Desferrioxamine</term>
<term>Dos</term>
<term>Drapier</term>
<term>Early schizonts</term>
<term>Effector</term>
<term>Elsevier science</term>
<term>Erythrocyte</term>
<term>Erythrocytic</term>
<term>Erythrocytic phase</term>
<term>Erythrocytic trophozoite</term>
<term>Falciparum</term>
<term>Falciparum malaria</term>
<term>Falciparum parasitemia</term>
<term>Ferritin</term>
<term>Food vacuole</term>
<term>Free radicals</term>
<term>Fritsch</term>
<term>Full consciousness</term>
<term>Glickstein</term>
<term>Gordeuk</term>
<term>Haematol</term>
<term>Helper type</term>
<term>Heme</term>
<term>Hemoglobin</term>
<term>Hemorrhagic injury</term>
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<term>Hershko</term>
<term>Hibbs</term>
<term>High affinity</term>
<term>Hnfbh</term>
<term>Host defense</term>
<term>Host hemoglobin</term>
<term>Human macrophages</term>
<term>Human malaria</term>
<term>Human monocytes</term>
<term>Hydrazone</term>
<term>Immune</term>
<term>Immune function</term>
<term>Immune response</term>
<term>Immunol</term>
<term>Infection</term>
<term>Infusion</term>
<term>Inhibitory</term>
<term>Inhibitory effect</term>
<term>Interferon</term>
<term>Intracellular</term>
<term>Iron</term>
<term>Iron chelation</term>
<term>Iron chelation therapy</term>
<term>Iron chelator</term>
<term>Iron chelators</term>
<term>Iron deficiency</term>
<term>Iron metabolism</term>
<term>Iron overload</term>
<term>Iron withholding</term>
<term>Isonicotinoyl</term>
<term>Labile</term>
<term>Labile pool</term>
<term>Late trophozoite</term>
<term>Libman</term>
<term>Life cycle</term>
<term>Lipophilicity</term>
<term>Loading dose</term>
<term>Loyevsky</term>
<term>Lytton</term>
<term>Mabeza</term>
<term>Macrophage</term>
<term>Malaria</term>
<term>Malaria cultures</term>
<term>Malaria parasites</term>
<term>Malarial</term>
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<term>Metabolism</term>
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<term>Natl</term>
<term>Neopterin</term>
<term>Nitric</term>
<term>Nitric oxide</term>
<term>Nitric oxide synthase</term>
<term>Oxide</term>
<term>Parasite</term>
<term>Parasite clearance</term>
<term>Parasite growth</term>
<term>Parasitemia</term>
<term>Parasitic infections</term>
<term>Parasitized</term>
<term>Parasitized erythrocytes</term>
<term>Parasitol</term>
<term>Parasitophorous</term>
<term>Parasitophorous vacuole</term>
<term>Pathogenesis</term>
<term>Pathway</term>
<term>Peroxidant</term>
<term>Peto</term>
<term>Pharmacol</term>
<term>Placebo</term>
<term>Plasma levels</term>
<term>Plasma transferrin</term>
<term>Plasmodial</term>
<term>Plasmodium</term>
<term>Plasmodium falciparum</term>
<term>Plasmodium falciparum malaria</term>
<term>Pollack</term>
<term>Ponka</term>
<term>Proc</term>
<term>Quinine</term>
<term>Recent study</term>
<term>Receptor</term>
<term>Reductase</term>
<term>Ribonucleotide</term>
<term>Ribonucleotide reductase</term>
<term>Rodriguez</term>
<term>Sadrzadeh</term>
<term>Salicylaldehyde isonicotinoyl hydrazone</term>
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<term>Subcellular membranes</term>
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<term>Toxic complexes</term>
<term>Transferrin</term>
<term>Transferrin receptors</term>
<term>Transferrin saturation</term>
<term>Transferrin saturations</term>
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<term>Tumor cells</term>
<term>Tumor necrosis factor</term>
<term>Uncomplicated</term>
<term>Uncomplicated falciparum</term>
<term>Unpublished observations</term>
<term>Vacuole</term>
<term>Vivax</term>
<term>Vivax malaria</term>
<term>Wachter</term>
<term>Weiss</term>
<term>Withholding iron</term>
<term>World health organization</term>
<term>Yinnon</term>
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<div type="abstract" xml:lang="en">Abstract: Malaria is one of the major global health problems, and an urgent need for the development of new antimalarial agents faces the scientific community. A considerable number of iron(III) chelators, designed for purposes other than treating malaria, have antimalarial activity in vitro, apparently through the mechanism of withholding iron from vital metabolic pathways of the intra-erythrocytic parasite. Certain iron(II) chelators also have antimalarial activity, but the mechanism of action appears to be the formation of toxic complexes with iron rather than the withholding of iron. Several of the iron(III)-chelating compounds also have antimalarial activity in animal models of plasmodial infection. Iron chelation therapy with desferrioxamine, the only compound of this nature that is widely available for use in humans, has clinical activity in both uncomplicated and severe malaria in humans.</div>
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